Microbial aromatization of steroids into equilin.
نویسندگان
چکیده
This report describes the bioconversion of 19-hydroxy-androsta-4, 7-diene-3, 17-dione into equilin with Nocardia rubra. Through mutation and improvement of medium and of conditions, the bioconversion could be improved to yield 40% equilin for a substrate concentration of 1 g/liter. Aromatization of several other 19-hydroxy and 19-nor substrates of the androstene series is reported, and the influence of various substitutions of the substrate molecule on aromatization is discussed.
منابع مشابه
Microbial aromatization of androsta-1, 4, 7- triene-3, 17-Dione.
Several microorganisms transform androsta-1, 4, 7-triene-3, 17-dione into equilin and equilenin, presumably via a 19-hydroxylated intermediate.
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ورودعنوان ژورنال:
- Applied microbiology
دوره 20 6 شماره
صفحات -
تاریخ انتشار 1970